TABLE 3.
Hematology parameters in SOCS-6−/− mice and wild-type littermates
| Parameter | Value for micea
|
|
|---|---|---|
| SOCS-6−/− (n = 12) | SOCS-6+/+ (n = 9) | |
| No. of peripheral white cells/μl | ||
| Total | 7,600 ± 3,150 | 7,450 ± 2,620 |
| Neutrophils | 980 ± 770 | 770 ± 520 |
| Lymphocytes | 5,960 ± 2,320 | 6,120 ± 1,970 |
| Monocytes | 520 ± 440 | 420 ± 230 |
| Eosinophils | 160 ± 120 | 140 ± 140 |
| No. of platelets/μl | 878,230 ± 147,460 | 906,190 ± 132,910 |
| Hematocrit (%) | 44 ± 2 | 45 ± 1 |
| Spleen | ||
| Wt (mg) | 82 ± 18 | 85 ± 21 |
| Blasts (%) | 2 ± 1 | 3 ± 2 |
| Myelocytes (%) | 0.2 ± 0.6 | 0.3 ± 0.7 |
| Neutrophils (%) | 3 ± 3 | 4 ± 3 |
| Lymphocytes (%) | 87 ± 6 | 84 ± 8 |
| Monocytes (%) | 2 ± 1 | 2 ± 1 |
| Eosinophils (%) | 0.6 ± 0.8 | 0.7 ± 0.7 |
| Nucleated RBC (%)b | 5 ± 3 | 7 ± 5 |
| Marrow | ||
| No. of cells/femur (106) | 38.9 ± 4.0 | 40.5 ± 6.0 |
| Blasts (%) | 1.4 ± 0.6 | 1.1 ± 0.7 |
| Myelocytes (%) | 3.0 ± 0.9 | 3.8 ± 1.7 |
| Neutrophils (%) | 14.0 ± 4.2 | 14.5 ± 2.9 |
| Lymphocytes (%) | 7.9 ± 2.4 | 7.4 ± 1.9 |
| Monocytes (%) | 3.3 ± 0.9 | 2.6 ± 1.0 |
| Eosinophils (%) | 1.3 ± 0.8 | 1.3 ± 0.7 |
| Nucleated RBC | 8.0 ± 2.1 | 9.9 ± 2.6 |
| Peritoneal cavity | ||
| Total cells (106) | 9.7 ± 3.6 | 6.2 ± 2.3 |
| Neutrophils (106) | 0 | 0 |
| Lymphocytes (106) | 4.1 ± 1.7 | 2.1 ± 0.9 |
| Macrophages (106) | 5.4 ± 2.2 | 3.9 ± 1.5 |
| Eosinophils (106) | 0.06 ± 0.14 | 0.03 ± 0.04 |
| Mast cells (106) | 0.14 ± 0.10 | 0.15 ± 0.10 |
a
Values are means ± standard deviations.
b
RBC, red blood cells.