TABLE 1.
Biochemical parameters of wild-type and mutant micea
| Diet and mouse type | Concn of:
|
|||
|---|---|---|---|---|
| ALT (U/liter) | Bilirubin U (mg/dl) | Bilirubin C (mg/dl) | Creatinine (mg/liter) | |
| RD | ||||
| Wild type | 21 ± 5 | <0.1 | <0.1 | 0.22 ± 0.08 |
| Mutant | 19 ± 4 | <0.1 | <0.1 | 0.18 ± 0.06 |
| RD + Phe | ||||
| Wild type | 25 ± 4 | <0.1 | <0.1 | 0.13 ± 0.01 |
| Mutant | 1,897 ± 17 | <0.1 | 0.56 ± 0.4 | 0.71 ± 0.7 |
a
Six mice per group. RD, regular diet; Phe, phenylalanine (20 mg/ml) added to drinking water for 10 days; ALT, alanine transaminase; bilirubin U and C, free and conjugated bilirubin, respectively.