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. 2002 Jul;22(13):4929–4942. doi: 10.1128/MCB.22.13.4929-4942.2002

FIG. 9.

FIG. 9.

The proapoptotic Bcl2 family protein Bid is not required for JNK-dependent apoptosis. (A) Bid is not required for JNK-dependent apoptosis. Wild-type and Bid−/− mouse fibroblasts were transfected with empty vector (control) or expression vectors for MKK7-JNK fusion proteins. Cell viability at 40 h posttransfection was examined using a luciferase reporter plasmid. The data presented represent the means ± SD of data obtained for three independent experiments. (B) Endogenous JNK is not required for apoptosis caused by ectopic expression of activated JNK. Wild-type and Jnk1−/− Jnk2−/− mouse fibroblasts were transfected with empty vector (control) or expression vectors for MKK7-JNK fusion proteins. Cell viability at 40 h posttransfection was examined using a luciferase reporter plasmid. The data presented represent the means ± SD of data obtained for three independent experiments.