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. 2026 May 26;26:561. doi: 10.1186/s12888-026-07948-8

Table 2.

Characteristics of included digital mindfulness and compassion-based intervention studies

Author (Year) Country Design Sample Size (N) Intervention Details Control Group Primary Outcome(s) Key Findings
Sun et al. (2021) [36] China RCT 168 (IG:84, CG:84) Self-guided Mindfulness: ’Spirits Healing’, 8-week smartphone app for mindfulness training. Waitlist

Depression: EPDS, PHQ-9

Anxiety: GAD-7

Effective for reducing perinatal depression and anxiety.
Yang et al. (2019) [37] China RCT 123 (IG:62, CG:61) Guided Mindfulness: 8-week WeChat program (videos/text/audio) guided by a multidisciplinary team. Waitlist

Depression: PHQ-9

Anxiety: SAS

Effective in reducing symptoms of antenatal depression and anxiety.
Smith et al. (2021) [38] USA RCT 101 (IG:50, CG:51) Digital Mindfulness: ’Calm’ app for mindfulness meditation. Waitlist

Depression: EPDS

Anxiety: GAD-7

Significant reduction in depression (Hedges’ g = -0.44) and anxiety (Hedges’ g = -0.44).
Zhang et al. (2021) [39] China RCT 108 (IG:54, CG:54) Digital Mindfulness: Mindfulness-Based Intervention (MBI) delivered via social media. Waitlist

Depression: EPDS

Anxiety: GAD-7

Significant reduction in depression (Hedges’ g = -0.61) and anxiety (Hedges’ g = -0.43).
Zhang et al. (2022) [40] China RCT 130 (IG:66, CG:64) Guided Mindfulness: Guided self-help Mindfulness-Based Intervention (MBI). Waitlist

Depression: EPDS

Anxiety: GAD-7

Significant reduction in depression (Hedges’ g = -0.57) and anxiety (Hedges’ g = -0.89).
Güney et al. (2022) [41] Turkey RCT 84 (IG:42, CG:42) Digital Mindfulness: Mindfulness-Based Stress Reduction (MBSR) program. Waitlist

Anxiety: BAI, CAQ

Depression: Not Assessed

Significant reduction in anxiety (Hedges’ g = -1.58).
Kelman et al. (2018) [42] USA RCT 40 (IG:22, CG:18) Digital Mindfulness: Internet-based Compassionate Mind Training (CMT). Waitlist

Depression: PHQ-2

Anxiety: GAD-2

Significant reduction in depression (Hedges’ g = -0.83). Non-significant reduction in anxiety (Hedges’ g = -0.54).
Carissoli et al. (2017) [43] Italy RCT 78 (IG:38, CG:40) Digital Mindfulness: App (“Benevolent Mind”) with daily relaxation, guided imagery, mood journal. Waitlist Anxiety: W-DEQ Non-significant reduction in anxiety (Hedges’ g = -0.05).
Matvienko-Sikar & Dockray (2017) [44] Ireland RCT 36 (IG:24, CG:12) Digital Mindfulness: Gratitude diary and mindfulness listening. Waitlist Depression: EPDS Non-significant reduction in depression (Hedges’ g = 0.63).
Krusche et al. (2018) [45] UK RCT 72 (IG:22, CG:50) Digital Mindfulness: Website (“Be Mindful Online”) with guided meditation. Waitlist

Depression: PHQ-2

Anxiety: GAD-2

Non-significant effect, trend favoring control for depression (g = 0.80) and anxiety (g = 0.46).
Doty et al. (2021) [46] USA RCT 41 (IG:20, CG:21) Digital Mindfulness: Mindfulness meditation program. Waitlist

Depression: PHQ-2

Anxiety: GAD-2

Non-significant reduction in depression (Hedges’ g = -0.58) and anxiety (Hedges’ g = -0.37).