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Amino acid alignment of Bam32, TAPP2, and TAPP1. Sequences were aligned with ClustalX, version 1.81. The PH domains are indicated by underlining. Stars indicate residues within the PH domain that are conserved among PH domains which bind to PI(3,4)P2 or PIP3 (24). Black shading indicates amino acid identities, and grey shading indicates amino acid similarities (as defined by ClustalX). (A) Mouse Bam32 and mouse TAPP2; (B) murine TAPP2 and human TAPP1.
