FIG. 9.

JDP-2 potentiates the partial agonist activity of RU486. Cos-1 cells were transfected with phPR-B (1.5 ng) and PRE₂-TATA-luc (200 ng) in the presence or absence of equimolar doses of pCR3.1-SRC-1 (50 to 200 ng) or pCR3.1-JDP-2 (34 to 137 ng). Cells were treated with vehicle, 10 nM RU486 (dark bars), or 10 nM R5020 (open bar) for the last 24 h of transfection. Severalfold hormone induction values were calculated as for Fig. 5, and values are averages ± SEM of three independent experiments.