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Altered serum lipid metabolite levels in mice lacking Pref-1. (A, B, and C) Levels of triglycerides, free fatty acids, and cholesterol in serum were measured from Pref-1-null and wild-type (WT) mice at 16 weeks of age after feeding on a high-fat diet from 3 to 16 weeks. Values are means ± standard errors with n = 5 to 8 per group. Statistics were performed with a two-tailed t test. ∗, P < 0.05; ∗∗, P < 0.01.
