TABLE 1.
Litter size, embryo and body weights, fat pad weights, lipid metabolites, and total lipid contents in livers of wild-type and Pref-1-null micea
| Variable | Sex | Mouse group
|
|
|---|---|---|---|
| Wild type | Pref-1 null | ||
| Litter size (no. of pups/litter) | 6.75 ± 0.32 (27) | 4.26 ± 0.26 (25)d | |
| Body wt (g) | |||
| E18.5 | 1.18 ± 0.003 (12) | 0.96 ± 0.004 (9)d | |
| 3 wk | Female | 8.51 ± 0.19 (27) | 7.34 ± 0.21 (32)d |
| Male | 8.81 ± 0.91 (27) | 7.58 ± 0.25 (37)d | |
| 16 wk | Female | 25.35 ± 0.50 (11) | 24.94 ± 0.99 (14) |
| Male | 35.72 ± 0.37 (16) | 35.60 ± 0.97 (14) | |
| Fat pad wt (% of body wt)b | |||
| 8 wk | Female | 3.33 ± 0.62 (10) | 3.80 ± 0.37 (7) |
| Male | 3.12 ± 0.34 (4) | 3.17 ± 0.33 (7) | |
| 16 wk | Female | 4.32 ± 0.38 (7) | 6.70 ± 0.50 (9)e |
| Male | 6.69 ± 0.49 (7) | 8.39 ± 0.29 (7)e | |
| Blood metabolites | |||
| Triglycerides (mg/liter) | Female | 8.82 ± 0.70 (5) | 12.0 ± 1.20 (6)f |
| Male | 11.1 ± 0.70 (5) | 19.6 ± 2.30 (6)e | |
| Cholesterol (mg/liter) | Female | 8.37 ± 0.63 (5) | 11.7 ± 1.34 (6)f |
| Male | 13.2 ± 0.54 (5) | 16.94 ± 0.85 (6)e | |
| Free fatty acids (mmol/liter) | Female | 1.56 ± 0.08 (5) | 1.79 ± 0.10 (6) |
| Male | 1.66 ± 0.14 (5) | 2.23 ± 0.18 (6)f | |
| Lipid content in liver (mg/g of liver)c | Female | 5.76 ± 0.31 (7) | 8.77 ± 0.57 (4)e |
| Male | 8.35 ± 0.44 (5) | 10.73 ± 0.69 (5)f | |
a
Values represent the average ± standard error of the mean. The number of samples is in parentheses.
b
The fat pad weights represent inguinal, retroperitoneal, and reproductive fats from mice 8 or 16 weeks of age.
c
Total lipid was extracted with a mixture of hexane-2-propanol(3/2 ratio) from mice 16 weeks of age.
d
P < 0.001.
e
P < 0.01.
f
P < 0.05.