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. 1986 Mar 1;292(6520):580–582. doi: 10.1136/bmj.292.6520.580

Content of low density lipoprotein receptors in breast cancer tissue related to survival of patients.

M J Rudling, L Ståhle, C O Peterson, L Skoog
PMCID: PMC1339562  PMID: 3081176

Abstract

The content of low density lipoprotein (LDL) receptors in tissue from primary breast cancers was determined and its prognostic information compared with that of variables of established prognostic importance. Frozen tumour specimens were selected, and tissue from 72 patients (32 of whom had died) were studied. The LDL receptor content showed an inverse correlation with the survival time. Analysis by a multivariate statistical method showed that the presence of axillary metastasis, content of receptors for oestrogen and LDL, diameter of the tumour, and DNA pattern were all of prognostic value with regard to patient survival. Improved methods of predicting survival time in patients with breast cancer may be of value in the choice of treatment for individual patients.

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Selected References

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  1. Auer G. U., Caspersson T. O., Wallgren A. S. DNA content and survival in mammary carcinoma. Anal Quant Cytol. 1980 Sep;2(3):161–165. [PubMed] [Google Scholar]
  2. Bonadonna G., Rossi A., Valagussa P., Banfi A., Veronesi U. The CMF program for operable breast cancer with positive axillary nodes. Updated analysis on the disease-free interval, site of relapse and drug tolerance. Cancer. 1977 Jun;39(6 Suppl):2904–2915. doi: 10.1002/1097-0142(197706)39:6<2904::aid-cncr2820390677>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  3. Brown M. S., Kovanen P. T., Goldstein J. L. Regulation of plasma cholesterol by lipoprotein receptors. Science. 1981 May 8;212(4495):628–635. doi: 10.1126/science.6261329. [DOI] [PubMed] [Google Scholar]
  4. Firestone R. A., Pisano J. M., Falck J. R., McPhaul M. M., Krieger M. Selective delivery of cytotoxic compounds to cells by the LDL pathway. J Med Chem. 1984 Aug;27(8):1037–1043. doi: 10.1021/jm00374a017. [DOI] [PubMed] [Google Scholar]
  5. Fisher E. R., Gregorio R. M., Fisher B., Redmond C., Vellios F., Sommers S. C. The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no. 4). Cancer. 1975 Jul;36(1):1–85. doi: 10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  6. Gambrell R. D., Jr Proposal to decrease the risk and improve the prognosis of breast cancer. Am J Obstet Gynecol. 1984 Sep 15;150(2):119–132. doi: 10.1016/s0002-9378(84)80002-2. [DOI] [PubMed] [Google Scholar]
  7. Goldstein J. L., Brown M. S. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem. 1977;46:897–930. doi: 10.1146/annurev.bi.46.070177.004341. [DOI] [PubMed] [Google Scholar]
  8. Ho Y. K., Smith R. G., Brown M. S., Goldstein J. L. Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood. 1978 Dec;52(6):1099–1114. [PubMed] [Google Scholar]
  9. Hynds S. A., Welsh J., Stewart J. M., Jack A., Soukop M., McArdle C. S., Calman K. C., Packard C. J., Shepherd J. Low-density lipoprotein metabolism in mice with soft tissue tumours. Biochim Biophys Acta. 1984 Oct 4;795(3):589–595. doi: 10.1016/0005-2760(84)90189-9. [DOI] [PubMed] [Google Scholar]
  10. Klintenberg C., Wallgren A., Bjelkenkrantz K., Carstenssen J., Humla S., Nordenskjöld B., Skoog L. DNA distribution, cytosol estrogen receptors and axillary nodes as prognostic predictors in breast carcinoma. Acta Radiol Oncol. 1985 May-Jun;24(3):253–258. doi: 10.3109/02841868509134396. [DOI] [PubMed] [Google Scholar]
  11. Krieger M., Smith L. C., Anderson R. G., Goldstein J. L., Kao Y. J., Pownall H. J., Gotto A. M., Jr, Brown M. S. Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. J Supramol Struct. 1979;10(4):467–478. doi: 10.1002/jss.400100409. [DOI] [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. Langer T., Strober W., Levy R. I. The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. J Clin Invest. 1972 Jun;51(6):1528–1536. doi: 10.1172/JCI106949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mehta R. G., Kute T. E., Hopkins M., Moon R. C. Retinoic acid binding proteins and steroid receptor levels in human breast cancer. Eur J Cancer Clin Oncol. 1982 Mar;18(3):221–226. doi: 10.1016/0277-5379(82)90040-2. [DOI] [PubMed] [Google Scholar]
  15. Mosley S. T., Goldstein J. L., Brown M. S., Falck J. R., Anderson R. G. Targeted killing of cultured cells by receptor-dependent photosensitization. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5717–5721. doi: 10.1073/pnas.78.9.5717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Norata G., Canti G., Ricci L., Nicolin A., Trezzi E., Catapano A. L. In vivo assimilation of low density lipoproteins by a fibrosarcoma tumour line in mice. Cancer Lett. 1984 Dec;25(2):203–208. doi: 10.1016/s0304-3835(84)80046-4. [DOI] [PubMed] [Google Scholar]
  17. Ong D. E., Chytil F. Retinoic acid-binding protein in rat tissue. Partial purification and comparison to rat tissue retinol-binding protein. J Biol Chem. 1975 Aug 10;250(15):6113–6117. [PubMed] [Google Scholar]
  18. Rose G., Shipley M. J. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523–526. doi: 10.1016/s0140-6736(80)92775-0. [DOI] [PubMed] [Google Scholar]
  19. Rudling M. J., Collins V. P., Peterson C. O. Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway. Cancer Res. 1983 Oct;43(10):4600–4605. [PubMed] [Google Scholar]
  20. Rudling M. J., Peterson C. O. A simple binding assay for the determination of low-density lipoprotein receptors in cell homogenates. Biochim Biophys Acta. 1985 Mar 6;833(3):359–365. doi: 10.1016/0005-2760(85)90091-8. [DOI] [PubMed] [Google Scholar]
  21. Rudling M. J., Peterson C. O. LDL receptors in bovine tissues assayed as the heparin-sensitive binding of 125I-labeled LDL in homogenates: relation between liver LDL receptors and serum cholesterol in the fetus and post term. Biochim Biophys Acta. 1985 Aug 22;836(1):96–104. doi: 10.1016/0005-2760(85)90225-5. [DOI] [PubMed] [Google Scholar]
  22. Vitols S. G., Masquelier M., Peterson C. O. Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts. J Med Chem. 1985 Apr;28(4):451–454. doi: 10.1021/jm00382a011. [DOI] [PubMed] [Google Scholar]
  23. Vitols S., Gahrton G., Ost A., Peterson C. Elevated low density lipoprotein receptor activity in leukemic cells with monocytic differentiation. Blood. 1984 May;63(5):1186–1193. [PubMed] [Google Scholar]
  24. Wallgren A., Silfverswärd C., Eklund G. Prognostic factors in mammary carcinoma. Acta Radiol Ther Phys Biol. 1976 Feb;15(1):1–16. doi: 10.3109/02841867609132703. [DOI] [PubMed] [Google Scholar]
  25. Wrange O., Nordenskjöld B., Gustafsson J. A. Cytosol estradiol receptor in human mammary carcinoma: an assay based on isoelectric focusing in polyacrylamide gel. Anal Biochem. 1978 Apr;85(2):461–475. doi: 10.1016/0003-2697(78)90243-9. [DOI] [PubMed] [Google Scholar]

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