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Conservation of the Sox10 export sequence in different species and within subgroup E. (A) The distinct functional NLSs and the NES are indicated within the Sox10 protein. TA, transactivation domain. NLSs (aa 105 to 121 and aa 176 to 179). NES (aa 134 to 145). (B) Comparison of the NES defined in this work with the corresponding sequences of Sox10 from other species and with other Sox proteins. (C) Consensus sequence of leucine-rich nuclear export signals as defined by Bogerd et al. (3).
