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Exportin inhibitor increases the activity of T311A but not the wild-type (WT) ERα. ERα-negative Ishikawa cells were transfected with 0.5 μg of EREe1bLuc, 0.5 μg of pLENβGal, and 0.1 μg of pLEN-hERα expressing wild-type or T311A ERα and treated overnight with vehicle, 17 β-estradiol (E2), leptomycin B (L), or a combination. ERα activity was expressed as a percentage of the activity in cells treated with 10−8 M 17β-estradiol but without leptomycin B.
