. Author manuscript; available in PMC: 2026 Jul 25.

Published in final edited form as: Semin Pediatr Neurol. 2025 Mar 12;53:101186. doi: 10.1016/j.spen.2025.101186

Table 2.

Molecular subgroups of Medulloblastoma

Molecular subgroup	WNT (10%)	SHH (30%)	Group 3 (25%)	Group 4 (35%)
Age	Child/AYA	Infancy/AYA	Early childhood	Childhood
Metastasis at dx	5%	15%	40%	35%
5-year OS	95%	75% (lower if TP53 mutant)	50%	75%
Genetic driver	CTNNB1 DDX3X	PTCH1, SUFU TP53	MYC/MYCN PVT	KDM6A SNCAIP
Syndrome	FAP	Gorlin, GPR16 ELP1, Li Fraumeni	BRCA1/2 PALB2	BRCA1/2 PALB2