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. 2026 Jul 13;17:1714655. doi: 10.3389/fimmu.2026.1714655

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Copyright © 2026 Zhan, Zhao, Zhang, Li, Zheng, Fu, Pan, Zhou, Xia, Chen, Xu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panel A presents a receiver operating characteristic (ROC) curve for age with an area under the curve (AUC) of 0.64. Panel B shows a ROC curve for NLR with an AUC of 0.62. Panel C displays a ROC curve for C3 with an AUC of 0.84. Each plot compares variable sensitivity versus specificity, with diagonal reference lines. — ROC curve analysis of age, NLR, and C3 for predicting severe disability (EDSS ≥ 4) in acute NMOSD.