Table 3.

Univariate and multivariate analyses of perioperative factors on the development of postoperative severe complications.

Characteristic	Univariable OR (95% CI)	P value	Multivariable OR (95% CI)	P value
Age >65 y	3.73 (2.49–5.60)	<0.001	2.14 (1.30–3.52)	0.003
ASA ≥III	3.18 (2.13–4.74)	<0.001	2.14 (1.36–3.37)	0.001
Preoperative NRS2002 ≥2	4.21 (2.48–7.15)	<0.001	1.97 (1.08–3.60)	0.028
Preoperative albumin <35 g/L	2.27 (1.53–3.37)	<0.001	2.05 (1.29–3.25)	0.003
POD2 nadir albumin <28.5 g/L	2.35 (1.62–3.41)	<0.001	1.55 (1.01–2.38)	0.044
Rocuronium ≥117.5 mg	3.72 (2.55–5.44)	<0.001	4.44 (2.92–6.75)	<0.001
Preoperative Hgb, g/L	0.99 (0.98–1.00)	0.027	—	—
Laparoscopic surgery	1.82 (1.10–3.02)	0.020	—	—

Final model uses clinically dichotomised predictors to match the nomogram. ΔAlb was non-significant (univariable OR 1.01, P = 0.185) and not retained; the continuous-variable model is reported as a sensitivity analysis (Supplementary Table 1). NRS2002, nutritional risk screening 2002; Hgb, haemoglobin; POD, postoperative day.