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. 2026 Jul 13;13:1909877. doi: 10.3389/fmolb.2026.1909877

FIGURE 2.

Illustration showing SERPINB7 and Legumain protein pathways. SERPINB7 limits calcium ion entry into the cell, influencing Golgi proteins, glycosylation, and regulatory gene expression for differentiation and inflammation, involving O-GalNAc glycosylation and cell adhesion proteins.

SERPINB7 regulates epidermal homeostasis through LGMN inhibition, glycosylation, and calcium signaling SERPINB7 restrains LGMN protease activity, thereby preserving proper O-GalNAc glycosylation and maintaining keratinocyte cohesion and structural integrity. In parallel, SERPINB7 supports intracellular calcium influx required for keratinocyte terminal differentiation and the expression of key barrier proteins such as filaggrin and loricrin. Through these coordinated pathways, SERPINB7 ensures epidermal barrier stability, limits antigen penetration, and helps prevent excessive cutaneous immune activation.