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. 2026 Jul 13;6:1766863. doi: 10.3389/fopht.2026.1766863

Table 1.

Timeline of the episode of care.

Timeframe Clinical event and interventions Findings and outcomes
~20 years prior to presentation Patient first noticed a mass on the left eye. A non-progressive, painless hyperpigmented mass on the left lacrimal caruncle.
1 month prior to presentation Onset of new ocular symptoms in the right eye. Progressive, painless visual loss in the right eye.
Initial presentation Comprehensive ophthalmic examination, MRI of the orbit, and metastatic work-up. Right eye (OD): hand motion vision, RAPD positive, choroidal mass with exudative retinal detachment (suggestive of melanoma).
Left eye (OS): 20/20 vision, papilliform pinkish lesion overlying a hyperpigmented caruncular mass.
Systemic: Metastatic work-up was unremarkable.
Surgical intervention Conducted under general anesthesia. OD: Enucleation.
OS: Complete excisional biopsy (no-touch technique) with double freeze–thaw cryotherapy to conjunctival edges.
Postoperative pathology Histopathological evaluation of the excised specimens. OD: Confirmed choroidal melanoma.
OS: Confirmed coexistence of a subepithelial nevus and a conjunctival papilloma.
12-month Follow-up Clinical follow-up examination. Patient remained stable with no evidence of tumor recurrence in either eye.

RAPD, relative afferent pupillary defect.