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. 2026 Jul 13;13:1862964. doi: 10.3389/fmed.2026.1862964

Figure 2.

Histopathology of a skin biopsy demonstrating non-specific psoriasiform changes, including hyperkeratosis, parakeratosis, acanthosis, and neutrophilic collections within the epidermis. No Sarcoptes scabiei mites or other parasitic structures were identified.

Histopathology of a skin biopsy (H&E stain, 10 × magnification) showed a thick hyperkeratotic stratum with areas of parakeratosis containing small plasma coagula and focal leukocyte collections. The epidermis showed significant irregular acanthosis, hyperplasia, and focal spongiosis, with neutrophilic collections forming pustules in the upper layers. The papillary dermis contained perivascular neutrophils and occasional lymphocytes, with some neutrophils present within vessel lumina. The deeper dermis was free of significant inflammation. No structures suggestive of Sarcoptes scabiei were identified. Histopathology demonstrated psoriasiform changes suggestive of psoriasis.