Table 1.
Reported cases of erythrodermic crusted scabies identified in the literature review (n = 16).
| Authors (year) | Age/sex | Initial diagnosis | Risk factors/immune status | Diagnostic test | Treatment | Outcome |
|---|---|---|---|---|---|---|
| Binić et al. (2009) (11) | 62/F | Erythroderma in relation to hypothyroidism | Elderly; systemic and topical corticosteroids | Skin scrapings | Topical 1% lindane; topical 25% benzyl benzoate; topical 10% sulfur ointment | Complete resolution |
| Garlatti et al. (2015) (12) | 72/F | Primary hypereosinophilic syndrome | Elderly; systemic corticosteroids | Dermoscopy; skin scrapings; histology | Not reported | Not reported |
| Cartron et al. (2020) (13) | Not reported/F | Erythrodermic psoriasis | Elderly; systemic corticosteroids | Histology | Topical 5% permethrin lotion, oral ivermectin 200 μg/kg on days 1, 2, 8, 9, and 15 | Clinical improvement; Death due to sepsis |
| Chen et al. (2024) (14) | 74/M | Eczema or psoriasis | Elderly; topical corticosteroids; Parkinson’s disease; hemiparesis | Skin scrapings; histology | Topical 20% sulfur cream | Clinical improvement; Death due to sepsis |
| Tolkachjov et al. (2018) (15) | 90/F | Recalcitrant contact dermatitis | Elderly; topical treatments; systemic corticosteroids; mycophenolate mofetil | Skin scrapings; histology | Oral ivermectin 200 μg/kg on days 1, 2, 8, 9, and 15; topical 5% permethrin; oral prednisone slowly tapered | Not reported |
| Devi and Hazarika (2021) (16) | 45/M | Erythrodermic psoriasis | Self-prescribed steroids (iatrogenic Cushing’s disease) | Skin scrapings | Oral ivermectin 200 μg/kg on days 1, 2, 8, 9, and 15; topical 5% permethrin cream; physiologic dose of prednisolone for iatrogenic Cushing’s disease | Resolution of hyperkeratotic plaques |
| Dragoš et al. (2004) (17) | 8/F | Juvenile dermatomyositis (confirmed earlier) with Gottron papules | Systemic and topical corticosteroids (for juvenile dermatomyositis) | Skin scrapings | Bland emollients and systemic antibiotic; topical 6% precipitated sulfur ointment | Complete resolution |
| Fonseca et al. (2013) (18) | 3/F | Erythrodermic psoriasis and onychomycosis | Down syndrome; topical corticosteroids; cyclosporine | Skin scrapings | Oral ivermectin 200 μg/kg once weekly for 4 weeks; topical 5% permethrin cream | Clinical improvement in nail dystrophy and no recurrence of keratoderma |
| Kulkarni et al. (2016) (19) | 71/M | Psoriasis, eczema, and cutaneous lymphoma in differential diagnoses | HIV | Skin scrapings; histology | Parenteral ceftriaxone; oral ivermectin 12 mg stat dose (repeated after 1 week); oral hydroxyzine; topical 5% permethrin cream; (urea 10% + lactic acid 10% + propylene glycol 10% + liquid paraffin 10%) cream; previous ART and AKT continued | Clinical improvement |
| Olamiju et al. (2023) (20) | 84/M | Not reported. Patient was treated for GPA | Azathioprine (for GPA) induced myelosupression; oral corticosteroids | Histology; skin scrapings | Topical 5% permethrin cream; oral ivermectin 200 μg/kg on days 1 and 10 | No recurrence of scabies |
| Paparizos et al. (2019) (21) | 55/M | Not reported | HIV (discontinuation of antiretroviral therapy), unsanitary conditions, and malnourishment | Skin scraping | Topical 25% benzyl benzoate; topical 5% urea/corticosteroid cream; oral antihistamines; long-acting betamethasone intramuscular injection; initiation of ART | Complete resolution |
| Piana et al. (2015) (22) | 75/M | Erythrodermic psoriasis or adverse drug reaction | Elderly; systemic corticosteroids | Histology | Topical 5% permethrin | Not reported |
| Ren et al. (2024) (23) | 78/F | “Senile pruritus, eczema, and hypereosinophilic dermatitis” | Elderly; topical and systemic corticosteroids | Dermoscopy; skin scrapings | Ivermectin 200 μg/kg once weekly for 4 weeks; sulfur ointment | Resolution |
| Shrestha and Bischof (2021) (24) | 73/M | Delay in diagnosis; erythroderma in relation to hypereosinophilia | Elderly; systemic corticosteroids | Skin scrapings (negative); histology (positive) | Topical permethrin; oral ivermectin; oral prednisone with gradual taper for scabies-induced hypereosinophilic syndrome | Significant improvement |
| Talty et al. (2022) (25) | 80/F | Crusted scabies considered in differential diagnoses along with atopic dermatitis, CTCL, psoriasis, and autoimmune connective tissue disease | Elderly; topical and systemic corticosteroids; dupilumab (?) | Histology | Oral ivermectin 200 μg/kg on days 1 and 10; topical 5% permethrin | Clinical improvement |
| Widaty et al. (2021) (26) | 32/M | Eczema | Topical and systemic corticosteroids | Skin scrapings; dermoscopy | Topical 5% permethrin; oral clindamycin; oral cetirizine; normal saline wet dressing on crusts and fissures; tapering of oral corticosteroid | Significant improvement |