Table 2.
WCRF/AICR dietary adherence, plasma metabolomic profiles, and incident lung cancer.
| Exposure | Contrast | Model | Participants | Cases | HR/SHR (95% CI) | P value |
|---|---|---|---|---|---|---|
| WCRF/AICR dietary score | Per 1-SD increment | Single-exposure | 91,917 | 470 | 0.989 (0.898, 1.089) | 0.821 |
| WCRF/AICR dietary score | Q2 vs. Q1 | Quartile model | 91,917 | 470 | 1.023 (0.798, 1.312) | 0.857 |
| WCRF/AICR dietary score | Q3 vs. Q1 | Quartile model | 91,917 | 470 | 1.041 (0.806, 1.345) | 0.756 |
| WCRF/AICR dietary score | Q4 vs. Q1 | Quartile model | 91,917 | 470 | 1.004 (0.759, 1.328) | 0.978 |
| WCRF/AICR dietary score | P for trend | Quartile model | 91,917 | 470 | 0.924 | |
| Diet-related plasma metabolomic signature | Per 1-SD increment | Single-exposure | 91,917 | 470 | 0.816 (0.752, 0.885) | <0.001 |
| FDR-restricted plasma bridge score | Per 1-SD increment | Single-exposure | 91,917 | 470 | 0.907 (0.823, 1.000) | 0.051 |
| Diet-related plasma metabolomic signature | Per 1-SD increment | Diet + signature + bridge | 91,917 | 470 | 0.822 (0.754, 0.896) | <0.001 |
| FDR-restricted plasma bridge score | Per 1-SD increment | Diet + signature + bridge | 91,917 | 470 | 0.949 (0.858, 1.049) | 0.305 |
| Fine-Gray competing risk | - | WCRF/AICR score | 91,917 | 470 | 0.992 (0.897, 1.096) | 0.871 |
| Fine-Gray competing risk | - | Plasma metabolomic signature | 91,917 | 470 | 0.830 (0.778, 0.885) | <0.001 |
| Fine-Gray competing risk | - | Plasma bridge score | 91,917 | 470 | 0.912 (0.824, 1.010) | 0.077 |
Models adjusted for age, sex, ethnicity, education, household income, smoking status, alcohol use, BMI, physical activity, diabetes, total energy intake, and number of valid dietary recalls.