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. 2026 Jul 13;17:1843796. doi: 10.3389/fimmu.2026.1843796

Figure 1.

Panel a shows a heatmap of gene expression grouped by IFN_LPS_Macrophage and IL4_Macrophage at various time points, with a principal component analysis (PCA) plot indicating clear separation between groups. Panel b presents a similar heatmap and PCA plot comparing IFN_TNF_Macrophage and IL4_Macrophage, also distinguishing expression patterns and group clustering.

Determination of alternative macrophage gene markers by the new CDBGE selector. Publicly available data on in vitro polarized macrophages from: (A) the mouse macrophage GSE158094 database and (B) the human macrophage GSE16385 database were used to develop the CDBGE selector. Left: heatmap of 10 selected genes/condition selector. Right: PCA scatterplot of the expression profile of the 10 selected genes for each condition. Percentages represent variance captured by Dimension (Dim) 1 and Dim 2.