Table 1.
Characteristics of patients categorized by FIB-4 quartiles.
| Parameters | Q1 (n=263) | Q2 (n=256) | Q3 (n=265) | Q4 (n=261) | P value |
|---|---|---|---|---|---|
| Male, n (%) | 135 (51.3%) | 148 (57.8%) | 153 (57.7%) | 160 (61.3%) | 0.136 |
| Age (years) | 52 (45, 60) | 58 (51, 63)* | 60 (53, 66)*# | 62 (56, 66)*# | <0.001 |
| BMI (kg/m2) | 26.0(23.6,29.3) | 25.7(23.5,28.1) | 25.5(23.7,27.8) | 24.9(23.4,27.7) | 0.072 |
| Smoking,n (%) | 85 (32.3%) | 98 (38.3%) | 93 (35.1%) | 110 (42.1%) | 0.110 |
| Drinking,n (%) | 75 (28.5%) | 92 (35.9%) | 87 (32.8%) | 99 (37.9%) | 0.116 |
| SBP (mmHg) | 132 (121, 146) | 134 (124, 145) | 132(123, 143) | 133(123, 145) | 0.640 |
| DBP (mmHg) | 83.9 ± 12.1 | 83.6 ± 10.4 | 81.1 ± 11.1 | 82.2 ± 12.1 | 0.017 |
| HN, n(%) | 137 (52.1%) | 133 (52.0%) | 153 (57.7%) | 138 (52.9%) | 0.494 |
| DPN, n (%) | 56 (21.3%) | 83 (32.4%)* | 71 (26.8%) | 75 (28.7%) | 0.037 |
| CAS, n (%) | 125 (47.5%) | 157 (61.3%)* | 175 (66.0%)* | 168 (64.4%)* | <0.001 |
| LEAD, n (%) | 150 (57.0%) | 177 (69.1%)* | 195 (73.6%)* | 196 (75.1%)* | <0.001 |
| FBG (mmol/L) | 7.3 (5.9, 9.7) | 7.1 (5.2, 9.8) | 6.8 (5.6, 9.3) | 7.0 (5.6, 9.2) | 0.399 |
| SUA (μmol/L) | 315(246,381) | 329 (267, 399) | 346(265, 412) | 330(258, 395) | 0.054 |
| Cr (μmol/L) | 59 (48, 72) | 62 (50, 71) | 61 (50, 73) | 62 (53, 73) | 0.056 |
| ALT (U/L) | 34 (21, 65) | 21 (16, 32)* | 17 (13, 24)*# | 16 (11, 23)*# | <0.001 |
| AST (U/L) | 14 (12, 17) | 17 (14, 20)* | 19 (16, 24)*# | 32(24,49)*#& | <0.001 |
| GGT (U/L) | 35 (21, 68) | 27 (18, 49)* | 22 (15, 34)*# | 22 (15, 36)*# | <0.001 |
| HbA1c (%) | 8.19 ± 2.10 | 8.41 ± 2.03 | 8.39 ± 2.12 | 8.55 ± 2.04 | 0.060 |
| TC (mmol/L) | 4.65(4.08,5.50) | 4.66 (4.02,5.47) | 4.80 (3.84,5.59) | 4.76 (4.04,5.62) | 0.739 |
| TG (mmol/L) | 1.67 (1.14,2.44) | 1.60 (1.13,2.51) | 1.67 (1.21, 2.43) |
1.68 (1.19, 2.49) |
0.831 |
| HDL (mmol/L) | 1.02 (0.88,1.25) | 1.04 (0.89,1.22) | 1.02 (0.88, 1.22) |
1.04 (0.88, 1.19) |
0.983 |
| LDL (mmol/L) | 2.84 (2.24,3.46) | 2.76 (2.22,3.42) | 2.85 (2.24, 3.51) |
2.91 (2.34, 3.52) |
0.697 |
Data are presented as median (interquartile range) or mean ± SD for continuous variables and n (%) for categorical variables. Continuous variables were compared using the Kruskal–Wallis test, except DBP and HbA1c (one-way ANOVA); categorical variables were compared using the chi-square test. Post-hoc pairwise comparisons: *p < 0.05 vs. Q1; #p < 0.05 vs. Q2; &p < 0.05 vs. Q3 (Mann–Whitney U or chi-square test with Bonferroni correction). BMI, body mass index; HN, hypertension; DPN, diabetic sensorimotor polyneuropathy; CAS, carotid atherosclerosis; LEAD, lower extremity arterial disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; SUA, serum uric acid; Cr, creatinine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, glutamyl transpeptidase; HbA1c, glycated hemoglobin A1c; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein.