Table 1.
Liver failure-related deaths and age-adjusted mortality rates among patients with digestive system malignant tumors in the United States.
| Characteristic | Deaths | AAMR | ||||
|---|---|---|---|---|---|---|
| 1999 | 2023 | Percent change (%) | 1999 (95% CI) | 2023 (95% CI) | AAPC (95% CI) | |
| Overall | 4131 | 3250 | -21.33 | 4.34 (4.21 to 4.47) | 2.08 (2.01 to 2.15) | -2.94 (-3.18 to -2.69)* |
| Sex | ||||||
| Female | 1608 | 1118 | -30.47 | 2.94 (2.80 to 3.09) | 1.40 (1.31 to 1.48) | -3.05 (-3.43 to -2.68)* |
| Male | 2523 | 2132 | -15.50 | 6.06 (5.82 to 6.30) | 2.92 (2.79 to 3.05) | -2.90 (-3.21 to -2.60)* |
| Age1 | ||||||
| 45–54 years | 578 | 357 | -38.24 | 1.58 (1.45 to 1.71) | 0.88 (0.79 to 0.97) | -2.49 (-3.92 to -1.03)* |
| 55–64 years | 871 | 941 | 8.04 | 3.66 (3.42 to 3.91) | 2.25 (2.10 to 2.39) | -2.07 (-2.87 to -1.26)* |
| 65–74 years | 1297 | 1161 | -10.49 | 7.04 (6.66 to 7.42) | 3.35 (3.15 to 3.54) | -2.89 (-3.54 to -2.24)* |
| 75–84 years | 1048 | 611 | -41.70 | 8.57 (8.05 to 9.09) | 3.33 (3.06 to 3.59) | -3.43 (-3.99 to -2.87)* |
| 85+ years | 337 | 180 | -46.59 | 8.11 (7.25 to 8.98) | 2.91 (2.48 to 3.33) | -3.93 (-5.03 to -2.81)* |
| Race | ||||||
| Hispanic | 302 | 463 | 53.31 | 5.77 (5.10 to 6.45) | 2.54 (2.30 to 2.77) | -3.11 (-3.90 to -2.32)* |
| NH Black | 456 | 432 | -5.26 | 5.34 (4.85 to 5.84) | 2.55 (2.30 to 2.79) | -2.88 (-3.35 to -2.40)* |
| NH White | 3141 | 2116 | -32.63 | 3.98 (3.84 to 4.12) | 1.97 (1.89 to 2.06) | -2.92 (-3.21 to -2.62)* |
| NH Other | 222 | 234 | 5.41 | 7.48 (6.45 to 8.51) | 2.15 (1.87 to 2.42) | -4.84 (-5.80 to -3.87)* |
| Urbanization2 | ||||||
| Metropolitan | 3429 | 2730 | -20.38 | 4.42 (4.27 to 4.57) | 2.01 (1.93 to 2.09) | -3.45 (-3.76 to -3.13)* |
| Nonmetropolitan | 702 | 520 | -25.93 | 3.95 (3.66 to 4.25) | 2.37 (2.17 to 2.57) | -2.00 (-2.55 to -1.45)* |
| Census region | ||||||
| Northeast | 884 | 557 | -36.99 | 4.48 (4.18 to 4.77) | 1.99 (1.82 to 2.16) | -3.05 (-3.56 to -2.54)* |
| Midwest | 811 | 638 | -21.33 | 3.63 (3.38 to 3.88) | 2.01 (1.85 to 2.17) | -2.35 (-2.87 to -1.84)* |
| South | 1419 | 1188 | -16.28 | 4.20 (3.98 to 4.42) | 2.00 (1.89 to 2.12) | -2.88 (-3.31 to -2.46)* |
| West | 1017 | 867 | -14.75 | 5.23 (4.91 to 5.55) | 2.48 (2.31 to 2.65) | -3.33 (-3.76 to -2.89)* |
| HHS region | ||||||
| HHS1 | 280 | 149 | -46.79 | 5.50 (4.85 to 6.14) | 1.95 (1.63 to 2.27) | -3.56 (-5.12 to -1.97)* |
| HHS2 | 400 | 251 | -37.25 | 4.11 (3.71 to 4.52) | 1.82 (1.59 to 2.04) | -3.15 (-3.74 to -2.55)* |
| HHS3 | 447 | 336 | -24.83 | 4.41 (4.00 to 4.82) | 2.25 (2.00 to 2.49) | -2.90 (-3.59 to -2.21)* |
| HHS4 | 714 | 629 | -11.90 | 3.72 (3.45 to 4.00) | 1.85 (1.71 to 2.00) | -2.85 (-3.26 to -2.43)* |
| HHS5 | 602 | 469 | -22.09 | 3.49 (3.21 to 3.77) | 1.88 (1.70 to 2.05) | -2.56 (-3.12 to -2.01)* |
| HHS6 | 484 | 406 | -16.12 | 4.75 (4.33 to 5.18) | 2.26 (2.03 to 2.48) | -2.45 (-3.35 to -1.54)* |
| HHS7 | 185 | 147 | -20.54 | 3.91 (3.34 to 4.47) | 2.20 (1.84 to 2.57) | -2.03 (-2.90 to -1.15)* |
| HHS8 | 106 | 138 | 30.19 | 3.84 (3.11 to 4.57) | 2.64 (2.19 to 3.09) | -1.00 (-2.05 to 0.06) |
| HHS9 | 797 | 514 | -35.51 | 6.24 (5.81 to 6.68) | 2.24 (2.05 to 2.44) | -4.55 (-5.14 to -3.94)* |
| HHS10 | 116 | 211 | 81.90 | 3.18 (2.60 to 3.76) | 3.10 (2.67 to 3.53) | 0.03 (-0.42 to 0.48) |
1
For age groups, AAMRs were replaced by crude mortality rates, and AAPCs were calculated based on crude mortality rates. 2For urbanization level, AAMR data for 2023 were unavailable; therefore, 2020 values were used, and AAPCs were calculated for 1999–2020. Asterisks (*) indicate statistical significance. AAMR, age-adjusted mortality rate; AAPC, average annual percent change; CI, confidence interval; HHS, U.S. Department of Health and Human Services; NH, non-Hispanic.