TABLE 3.
Risk for Clostridioides difficile infection in the ICU.
| Risk factors | CDI (%) | No CDI | OR (95%CI) | P |
|---|---|---|---|---|
| Age≥65 years | | | 1.11 (0.97–1.27) | 0.151 |
| Yes | 493 (1.6) | 30,994 | | |
| No | 380 (1.4) | 26,432 | | |
| Sex | | | 1.12 (0.98–1.28) | 0.093 |
| Male | 460 (1.4) | 31,910 | | |
| Female | 413 (1.6) | 25,516 | | |
| BMI≥30 | | | 1.40 (1.22–1.60) | <0.001 |
| Yes | 401 (1.8) | 21,710 | | |
| No | 472 (1.3) | 35,716 | | |
| AIDS | | | 1.76 (0.72–4.30) | 0.206 |
| Yes | 5 (2.6) | 187 | | |
| No | 868 (1.5) | 57,239 | | |
| Cancer | | | 1.69 (1.39–2.06) | <0.001 |
| Yes | 116 (2.4) | 4,764 | | |
| No | 757 (1.4) | 52,662 | | |
| CHF | | | 1.13 (0.96–1.33) | 0.138 |
| Yes | 189 (1.6) | 11,278 | | |
| No | 684 (1.5) | 46,148 | | |
| COPD | | | 1.18 (0.98–1.41) | 0.074 |
| Yes | 148 (1.7) | 8,491 | | |
| No | 725 (1.5) | 48,935 | | |
| Dementia | | | 1.29 (0.87–1.91) | 0.210 |
| Yes | 26 (1.9) | 1,339 | | |
| No | 847 (1.5) | 56,087 | | |
| Diabetes | | | 1.81 (1.56–2.11) | <0.001 |
| Yes | 242 (2.4) | 10,021 | | |
| No | 631 (1.3) | 47,405 | | |
| IBD | | | 2.76 (1.56–4.91) | 0.001 |
| Yes | 13 (6.1) | 201 | | |
| No | 531 (2.1) | 25,345 | | |
| Renal disease | | | 2.18 (1.86–2.55) | <0.001 |
| Yes | 209 (2.8) | 7,252 | | |
| No | 664 (1.3) | 50,174 | | |
| Insulin | | | 1.36 (1.19–1.56) | <0.001 |
| Yes | 469 (1.7) | 26,406 | | |
| No | 404 (1.3) | 31,020 | | |
| High risk antibiotics | | | 2.11 (1.83–2.42) | <0.001 |
| Yes | 558 (2.1) | 26,239 | | |
| No | 315 (1.0) | 31,187 | | |
| Immunosuppression | | | 1.09 (0.93–1.28) | 0.264 |
| Yes | 203 (1.6) | 12,451 | | |
| No | 670 (1.5) | 44,975 | | |
Abbreviations: CDI, Clostridioides difficile infection; OR, odds ratio; CI, confidence interval; BMI, body mass index; AIDS, acquired immunodeficiency syndrome; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; IBD, inflammatory bowel disease.