Skip to main content
. 2026 Jul 13;17:1827585. doi: 10.3389/fneur.2026.1827585

Table 5.

Factors associated with SDS in patients with MOH.

Characteristic B P-value 95.0% CI for B Collinearity statistics
Lower bound Upper bound Tolerance VIF
(Constant) −2.511 0.487 −9.644 4.622
Age 0.037 0.239 −0.025 0.098 0.715 1.399
Female sex 0.384 0.527 −0.816 1.584 0.628 1.591
BMI −0.015 0.758 −0.111 0.081 0.782 1.279
Duration of MOH 0.020 0.844 −0.181 0.221 0.855 1.170
Type of primary headache disorder Tension-type headache −1.112 0.063 −2.287 0.063 0.759 1.317
Cluster headache −1.385 0.163 −3.337 0.567 0.740 1.352
MHD −0.091 0.199 −0.231 0.049 0.273 3.664
AMD 0.254 0.002* 0.092 0.416 0.240 4.173
HIT-6 total score 0.086 0.046* 0.002 0.170 0.732 1.366
DASS-12 total score −0.071 0.075 −0.148 0.007 0.435 2.301
SURPS total score 0.031 0.368 −0.037 0.100 0.448 2.234
Heavy caffeine consumption −0.460 0.544 −1.955 1.035 0.476 2.102
CUDQ total score 0.160 0.002* 0.060 0.260 0.369 2.711

AMD, acute medication days; BMI, body mass index; CUDQ, Caffeine Use Disorder Questionnaire; DASS-12, Depression Anxiety Stress Scales–12; HIT-6, Headache Impact Test–6; MHD, monthly headache days; MOH, medication overuse headache; SDS, Severity of Dependence Scale; SURPS, Substance Use Risk Profile Scale.

Adjusted R square = 0.236.

*P-value < 0.05 is considered significant.