Table 6.
Mediation effect analysis of CSI and MLD on radiation pneumonitis.
| Effect type | Total effect | Direct effect | Indirect effect (CSI1→MLD2→RP3) |
|---|---|---|---|
| Coefficient B | 3.116 | 1.732 | 3.768 |
| Exp(B) | 22.560 | 5.654 | 43.305 |
| 95% BCa CI4 | 9.480∼53.694 | 1.768∼18.080 | -- |
| P | <0.001 | 0.003 | <0.001 |
| Proportion of mediation effect | -- | -- | 120.924% |
The 95% confidence interval of the indirect effect was calculated using 1000 bias-corrected and accelerated (BCa) bootstrap resamples. 1CSI, chest wall + supraclavicular + internal mammary lymph node irradiation; 2MLD: mean lung dose; 3RP, radiation pneumonitis; 4BCa CI, bias-corrected and accelerated confidence interval.