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. 2026 Jul 13;17:1880997. doi: 10.3389/fphar.2026.1880997

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Copyright © 2026 Satria, Kusuma, Isnani, Sukorini, Ratnaningsih, Herningtyas, Intansari, Windarwati, Harahap, Syaifullah, Hikmatul, Bodiwan, Prabasaktya, Santoso, Darmawan, Mugiyanto, Ardianto, Irham, Lin, Chen and Adikusuma.

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Four microscopic images of stained tissue samples display clusters of cells with prominent dark purple nuclei and varying granularity, surrounded by lighter-stained cellular structures; scale bars indicate 15 micrometers for reference. — Bone marrow aspirate findings demonstrating excessive lipid-laden macrophages. Numerous enlarged macrophages with abundant, finely vacuolated cytoplasm are present, indicating intracellular lipid accumulation. These features are consistent with lipid-laden macrophages exhibiting prominent cytoplasmic vacuolization suggestive of intracellular lipid accumulation. All images were obtained from one of the twins, as a bone marrow procedure could not be performed in the other due to clinical deterioration.