Table 3.
A summary of cBioPortal samples with A127 equivalent mutations in other H2A variants.
| Tumor tissue | Normal tissue | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Sample ID | Cancer type detailed | Chr. | Start pos | End pos | Ref | Var | Protein change | Variant reads | Ref reads | VAF | Variant reads | Ref reads | VAF |
| H2AC1 | IC-9635EPN | Ependymoma (Glioma) | 6 | 25726374 | 25726374 | C | A | A128S | 25 | 22 | 0.53 | 25 | 22 | 0.53 |
| H2AC4 | TCGA-AA-3492-01 | Colon Adenocarcinoma | 6 | 26033417 | 26033417 | G | A | A127V | 32 | 33 | 0.49 | 0 | 52 | 0 |
| H2AC15 | CSCC-32-T | Cutaneous Squamous Cell Carcinoma | 6 | 27805739 | 27805739 | C | A | A127S | 31 | 125 | 0.2 | 0 | 178 | 0 |
| H2AC17 | cll_iuopa_2015_464 | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 6 | 27860548 | 27860548 | G | C | A127G | – | – | – | – | – | – |
| H2AC17 | DLBCL-LS2357 | Diffuse Large B-Cell Lymphoma, NOS | 6 | 27860548 | 27860548 | G | A | A127V | 12 | 111 | 0.1 | – | – | – |
| H2AC17 | SP116697 | Diffuse Large B-Cell Lymphoma, NOS | 6 | 27860549 | 27860549 | C | T | A127T | 4 | 30 | 0.12 | – | – | – |
| H2AC17 | PCNSL_3 | Diffuse Large B-Cell Lymphoma, NOS | 6 | 27860548 | 27860548 | G | A | A127V | – | – | – | – | – | – |
| H2AC17 | SCLL-0363* | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 6 | 27860548 | 27860548 | G | C | A127G | 55 | 46 | 0.54 | 0 | 77 | 0 |
| H2AC17 | SCLL-0363* | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 6 | 27860549 | 27860549 | C | T | A127T | 56 | 49 | 0.53 | 0 | 80 | 0 |
| H2AC20 | CLCA_0273 | Hepatocellular Carcinoma | 1 | 149858901 | 149858901 | C | T | A126V | – | – | – | – | – | – |
| H2AC25 | TCGA-23-1116-01 | Serous Ovarian Cancer | 1 | 228645139 | 228645139 | G | T | A127D | 125 | 49 | 0.72 | 0 | 60 | 0 |
VAF, variant allele frequency. *Two substitutions at the same codon are present in this sample.