Table 2.
Multivariable logistic regression and multivariable cox proportional hazards regression analyses of the association between serum adropin and prevalent/incident DKD.
| Method/Level | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| OR/HR (95% CI) |
P-value | OR/HR (95% CI) |
P-value | OR/HR (95% CI) |
P-value | |
| Logistic | ||||||
| adropin | 0.82 (0.70,0.95) | 8.84×10-3 | 0.82 (0.70, 0.96) | 1.26×10-2 | 0.83(0.71,0.96) | 1.53×10-2 |
| Q1 | Ref. | Ref. | Ref. | |||
| Q2 | 0.63 (0.32, 1.23) | 1.85×10-1 | 0.64 (0.32, 1.24) | 1.92×10-1 | 0.63 (0.31, 1.23) | 1.83×10-1 |
| Q3 | 0.50 (0.23, 1.01) | 5.97×10-2 | 0.51 (0.24, 1.04) | 7.27×10-2 | 0.53 (0.25, 1.08) | 8.93×10-2 |
| Q4 | 0.32 (0.12, 0.71) | 8.29×10-3 | 0.34 (0.13, 0.75) | 1.26×10-2 | 0.35 (0.14, 0.78) | 1.52×10-2 |
| P trend | 4.13×10-3 | 6.82×10-3 | 9.07×10-3 | |||
| Cox | ||||||
| adropin | 0.88 (0.85, 0.91) | 9.69×10-11 | 0.88 (0.85, 0.91) | 9.61×10-11 | 0.88 (0.85, 0.91) | 8.40×10-11 |
| Q1 | Ref. | Ref. | Ref. | |||
| Q2 | 0.84 (0.70, 1.02) | 7.39×10-2 | 0.84 (0.70, 1.02) | 6.91×10-2 | 0.84 (0.70, 1.01) | 6.67×10-2 |
| Q3 | 0.73 (0.60, 0.88) | 1.09×10-3 | 0.75 (0.62, 0.91) | 3.18×10-3 | 0.75 (0.62, 0.91) | 3.34×10-3 |
| Q4 | 0.46 (0.37, 0.57) | 3.37×10-12 | 0.45 (0.36, 0.57) | 2.77×10-12 | 0.45 (0.36, 0.56) | 2.42×10-12 |
| P trend | 1.03×10-12 | 1.83×10-12 | 1.73×10-12 | |||
a Model 1 was an unadjusted model including only Adropin.
b Model 2 was adjusted for age, sex, body mass index (BMI), smoking status, and alcohol consumption.
c Model 3 was further adjusted for hypertension and medication use based on Model 2.