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. 2026 Jul 13;16:1867715. doi: 10.3389/fonc.2026.1867715

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Copyright © 2026 Li, Liu, Xu, Fang, Sun, Yan, Cao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panel of three grayscale axial brain MRI images labeled A, B, and Cshowing progressive changes in a right-sided brain lesion before and after intervention,with dark spots visible in panels B and C indicating implanted ¹²⁵I seeds. — Symptomatic brain edema after ¹²⁵I seed implantation in a patient with recurrent glioblastoma. (A) Preoperative contrast-enhanced MRI showing the tumor in the right parietal lobe with surrounding peritumoral edema. (B) One week after ¹²⁵I seed implantation, the patient developed headache and left hemiparesis. MRI confirmed postoperative brain edema. One-week treatment with mannitol and corticosteroids resulted in significant symptomatic relief. (C) There-month follow-up MRI showed marked reduction in tumor enhancement and significant alleviation of brain edema compared with baseline.