Table 4. Comparison of histological parameters among the Control, Hirudoid, Silverdin, and Hirudoid + Silverdin groups.
| Control | Hirudoid | Silverdin | Hirudoid + Silverdin | p | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Median | IQR | Mean ± SD | Median | IQR | Mean ± SD | Median | IQR | Mean ± SD | Median | IQR | ||
| SD, standard deviation; IQR, inter quartile range; TGF-β1, transforming growth factor-beta 1; * Kruskal-Wallis Variance Analysis. | |||||||||||||
| Histological SPOT score | 5.63 ± 1.65 | 5.5 | 4-7 | 6.00 ± 1.69 | 6.0 | 4-7 | 6.38 ± 1.68 | 5.5 | 5-8 | 6.25 ± 1.28 | 6 | 5-7 | 0.844* |
| Hypertrophic Index (HI) | 1.73 ± 0.26 | 1.79 | 1.42-1.97 | 1.51 ± 0.14 | 1.55 | 1.46-1.59 | 1.63 ± 0.11 | 1.65 | 1.56-1.74 | 1.63 ± 0.19 | 1.59 | 1.46-1.83 | 0.263* |
| Collagen Index (CI) | 49.80 ± 4.98 | 50.53 | 48.68-53.08 | 50.61 ± 4.09 | 50.15 | 47.95-54.94 | 48.33 ± 5.36 | 47.73 | 44.49-51.74 | 50.64 ± 3.58 | 51.40 | 47.75-51.81 | 0.684* |
| Fibroblast density | 7116.50 ± 1427.50 | 7380 | 5675-8435 | 8707.75 ± 2202.18 | 8804 | 6646-10350 | 8124.25 ± 1579.74 | 8271 | 6626-9740 | 8901.75 ± 2279.77 | 9350 | 6671-10490 | 0.246* |
| Immunohistochemical TGF-β1 H-score | 48.72 ± 14.33 | 50.9 | 34.7-59.3 | 57.67 ± 20.93 | 59.4 | 44.3-78.2 | 21.55 ± 9.97 | 21.0 | 15.9-26.4 | 40.57 ± 13.12 | 38.3 | 28.9-49.8 | 0.002* |