4-HNE	4-hydroxynonenal
4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1
AA	Arachidonic acid
ACSL4	Acyl-CoA synthetase long-chain family member 4
AdA	Adrenic acid
AIFM2	Apoptosis-inducing factor mitochondria-associated 2
ALOX12	Arachidonate 12-lipoxygenase
ALOX15	Arachidonate 15-lipoxygenase
AML	Acute myeloid leukemia
APEX2	Ascorbate peroxidase 2
ARE	Antioxidant response element
ATP	Adenosine triphosphate
AUC	Area under the curve
A16	Sulfonyl ynamide-based covalent GPX4 inhibitor A16
BH4	Tetrahydrobiopterin
BioID	Biotin identification
Breg	Regulatory B cell
ccRCC	Clear cell renal cell carcinoma
cGAS	Cyclic GMP-AMP synthase
Ch25h	Cholesterol 25-hydroxylase
CoQ10	Coenzyme Q10
CRPC	Castration-resistant prostate cancer
CRT	Calreticulin
CUL3	Cullin 3
CXCR2	C-X-C chemokine receptor type 2
DAMPs	Damage-associated molecular patterns
DCs	Dendritic cells
DHFR	Dihydrofolate reductase
DHODH	Dihydroorotate dehydrogenase
DUBs	Deubiquitinases
EBI2	Epstein–Barr virus–induced G protein-coupled receptor 2
EPR	Enhanced permeability and retention
erastin	Ferroptosis inducer erastin
FIN56	Ferroptosis-inducing 56
FSP1	Ferroptosis suppressor protein 1
GCH1	GTP cyclohydrolase 1
GENIE	Genomics Evidence Neoplasia Information Exchange
GPX4	Glutathione peroxidase 4
GR1	Granulocyte differentiation antigen 1
GSH	Glutathione
GSSG	Glutathione disulfide
HCC	Hepatocellular carcinoma
HIF-1α	Hypoxia-inducible factor 1α
HIFs	Hypoxia-inducible factors
HIM-PROTAC	GPX4-targeting proteolysis-targeting chimera HIM-PROTAC
HMGB1	High mobility group box 1
HMGA2	High mobility group AT-hook 2
HNSCC	Head and neck squamous cell carcinoma
HO-1	Heme oxygenase 1
Hsp70	Heat shock protein 70
ICD	Immunogenic cell death
ICB	Immune checkpoint blockade
IFN-γ	Interferon-γ
IL-15	Interleukin-15
IL-2	Interleukin-2
JAK	Janus kinase
JKE-1674	Active metabolite of ML210
KEAP1	Kelch-like ECH-associated protein 1
kcat/KM	Catalytic efficiency
LC-MS/MS	Liquid chromatography-tandem mass spectrometry
LPCAT3	Lysophosphatidylcholine acyltransferase 3
LPS	Lipopolysaccharide
MDA	Malondialdehyde
MDSCs	Myeloid-derived suppressor cells
MHC	Major histocompatibility complex
ML162	Covalent GPX4 inhibitor ML162
ML210	Covalent GPX4 inhibitor ML210
MSI	Mass spectrometry imaging
MSK-IMPACT	Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets
MTTP	Microsomal triglyceride transfer protein
mTORC1	Mechanistic target of rapamycin complex 1
NADPH	Nicotinamide adenine dinucleotide phosphate
NFE2L2	Nuclear factor, erythroid 2-like 2
NK cells	Natural killer cells
NQO1	NAD(P)H quinone dehydrogenase 1
Nrf2	Nuclear factor erythroid 2-related factor 2
NSCLC	Non-small cell lung cancer
OS	Overall survival
PC	Phosphatidylcholine
PD-1	Programmed cell death protein 1
PD-L1	Programmed death-ligand 1
PE	Phosphatidylethanolamine
PF-670462	ZDHHC8 inhibitor PF-670462
PFS	Progression-free survival
PLK1	Polo-like kinase 1
PPARγ	Peroxisome proliferator-activated receptor gamma
PROTACs	Proteolysis-targeting chimeras
PUFAs	Polyunsaturated fatty acids
RES	Reticuloendothelial system
ROS	Reactive oxygen species
RSL3	Ras-selective lethal 3
SAR	Structure-activity relationship
SAT1	Spermidine/spermine N1-acetyltransferase 1
Sec	Selenocysteine
shRNA	Short hairpin RNA
SLC7A11	Solute carrier family 7 member 11
S6K	Ribosomal protein S6 kinase
STAT1	Signal transducer and activator of transcription 1
STING	Stimulator of interferon genes
system x_c−	Cystine/glutamate antiporter system x_c−
TAMs	Tumor-associated macrophages
TCGA	The Cancer Genome Atlas
TILs	Tumor-infiltrating lymphocytes
TME	Tumor microenvironment
TNBC	Triple-negative breast cancer
TRIM26	Tripartite motif containing 26
Treg cells	Regulatory T cells
TRM	Tissue-resident memory T cells
Ub	Ubiquitin
USP8	Ubiquitin-specific peptidase 8
VHL	Von Hippel-Lindau
ZDHHC8	Zinc finger DHHC-type palmitoyltransferase 8
ZDHHC20	Zinc finger DHHC-type palmitoyltransferase 20