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. 2026 Jul 20;18(14):2335. doi: 10.3390/cancers18142335
AASLD American Association for the Study of Liver Diseases
ABCB1 ATP-Binding Cassette Subfamily B Member 1 (P-glycoprotein/P-gp)
ABCC1 ATP-Binding Cassette Subfamily C Member 1 (MRP1)
ABCG2 ATP-Binding Cassette Subfamily G Member 2
AEG-1 Astrocyte Elevated Gene-1 (also known as Metadherin/MTDH)
AFP Alpha-Fetoprotein
AGO2 Argonaute 2
ALK5 Activin Receptor-Like Kinase 5
Ang-1 Angiopoietin-1
Ang-2 Angiopoietin-2
APC Adenomatous Polyposis Coli
ASGPR Asialoglycoprotein Receptor
ASO Antisense Oligonucleotide
ATF6 Activating Transcription Factor 6
ATP Adenosine Triphosphate
ATRA All-Trans Retinoic Acid
AXIN1 Axis Inhibition Protein 1
BCL-2 B-Cell Lymphoma 2
BIM BCL-2-Like Protein 11 (pro-apoptotic)
BiP/GRP78 Binding Immunoglobulin Protein/Glucose-Regulated Protein 78
β-catenin Beta-Catenin (CTNNB1 protein product)
β-oxidation Beta-Oxidation (mitochondrial fatty acid oxidation pathway)
β-TRCP Beta-Transducin Repeat-Containing Protein (E3 ubiquitin ligase)
c-Myc Cellular Myelocytomatosis Proto-Oncogene
CBP CREB-Binding Protein
CCL2 C-C Motif Chemokine Ligand 2
CD8+ Cluster of Differentiation 8 (cytotoxic T cells)
CD163 Cluster of Differentiation 163 (M2 macrophage marker)
CD206 Cluster of Differentiation 206 (Mannose Receptor)
CDKN1A Cyclin-Dependent Kinase Inhibitor 1A (p21)
CHOP C/EBP Homologous Protein
CI Confidence Interval
CSC Cancer Stem Cell
CTLA-4 Cytotoxic T-Lymphocyte-Associated Protein 4
CTNNB1 Catenin Beta-1 (β-catenin gene)
DAGs Diacylglycerols
DAMPs Damage-Associated Molecular Patterns
DEN Diethylnitrosamine
dsDNA Double-Stranded DNA
EASL European Association for the Study of the Liver
ECM Extracellular Matrix
EGF Epidermal Growth Factor
EGFR Epidermal Growth Factor Receptor
eIF2α Eukaryotic Initiation Factor 2 Alpha
EMT Epithelial-to-Mesenchymal Transition
ER Endoplasmic Reticulum
ERAD ER-Associated Degradation
EVs Extracellular Vesicles
FAK Focal Adhesion Kinase
FASN Fatty Acid Synthase
FFA Free Fatty Acid
FGF Fibroblast Growth Factor
FSP1 Ferroptosis Suppressor Protein 1
GalNAc N-Acetylgalactosamine
GPX4 Glutathione Peroxidase 4
GRP94 Glucose-Regulated Protein 94
GSH Reduced Glutathione
GSK3β Glycogen Synthase Kinase 3 Beta
HBV Hepatitis B Virus
HCC Hepatocellular Carcinoma
HCV Hepatitis C Virus
HGF Hepatocyte Growth Factor
HIF-1α Hypoxia-Inducible Factor-1 Alpha
HIF-2α Hypoxia-Inducible Factor-2 Alpha
HIV-1 Human Immunodeficiency Virus Type 1
HMGB1 High Mobility Group Box 1
HSCs Hepatic Stellate Cells
IGF1 Insulin-Like Growth Factor 1
IKK IκB Kinase
IKKβ IκB Kinase Beta
IL-1β Interleukin-1 Beta
IL-4 Interleukin-4
IL-6 Interleukin-6
IL-10 Interleukin-10
IL-12 Interleukin-12
IL-13 Interleukin-13
IRE1α Inositol-Requiring Enzyme 1 Alpha
JNK c-Jun N-Terminal Kinase
KASL Korean Association for the Study of the Liver
KCs Kupffer Cells
LAG-3 Lymphocyte Activation Gene-3
LEF Lymphoid Enhancer-Binding Factor
LNPs Lipid Nanoparticles
LPCs Lysophosphatidylcholines
LPS Lipopolysaccharide
LXXLL Leucine-X-X-Leucine-Leucine (nuclear receptor-binding motif)
MAFLD Metabolic Dysfunction-Associated Fatty Liver Disease
MASH Metabolic Dysfunction-Associated Steatohepatitis
MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease
MDM2 Mouse Double Minute 2 Homolog
MDR Multidrug Resistance
MEK Mitogen-Activated Protein Kinase Kinase
miRNA MicroRNA
MLKL Mixed Lineage Kinase Domain-Like Pseudokinase
mRNA Messenger RNA
MRI Magnetic Resonance Imaging
MRP1 Multidrug Resistance-Associated Protein 1 (ABCC1)
MTDH Metadherin (also known as AEG-1)
mTOR Mechanistic Target of Rapamycin
MTORC1 mTOR Complex 1
NF-κB Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
NLRP3 NLR Family Pyrin Domain-Containing 3 (inflammasome)
p21 Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A)
p53 Tumor Protein p53
PAMAM Polyamidoamine (dendrimer)
PD-1 Programmed Cell Death Protein 1
PD-L1 Programmed Death-Ligand 1
PDGF-BB Platelet-Derived Growth Factor BB
PDGFR Platelet-Derived Growth Factor Receptor
PERK Protein Kinase RNA-Like ER Kinase
P-gp P-Glycoprotein (ABCB1)
PI3K Phosphoinositide 3-Kinase
PlGF Placental Growth Factor
PPARα Peroxisome Proliferator-Activated Receptor alpha
PPIs Protein–Protein Interactions
PTEN Phosphatase and Tensin Homolog
PUMA p53 Upregulated Modulator of Apoptosis
Raf Rapidly Accelerated Fibrosarcoma Kinase
RIPK1 Receptor-Interacting Serine/Threonine-Protein Kinase 1
RIPK3 Receptor-Interacting Serine/Threonine-Protein Kinase 3
RISC RNA-Induced Silencing Complex
RNAi RNA Interference
ROS Reactive Oxygen Species
scRNA-seq Single-Cell RNA Sequencing
Shh Sonic Hedgehog
siRNA Small Interfering RNA
SLC7A11 Solute Carrier Family 7 Member 11 (system Xc transporter)
α-SMA Alpha-Smooth Muscle Actin
SMAD2 SMAD Family Member 2
SMAD3 SMAD Family Member 3
SMAD4 SMAD Family Member 4
SND1 Staphylococcal Nuclease Domain-Containing 1
STAT3 Signal Transducer and Activator of Transcription 3
STING Stimulator of Interferon Genes
TAMs Tumor-Associated Macrophages
TCF T Cell Factor
TGF-α Transforming Growth Factor Alpha
TGF-β1 Transforming Growth Factor Beta 1
TGFβRII Transforming Growth Factor Beta Receptor II
TIM-3 T Cell Immunoglobulin and Mucin Domain-Containing Protein 3
TIMPs Tissue Inhibitors of Metalloproteinases
TKIs Tyrosine Kinase Inhibitors
TLR4 Toll-Like Receptor 4
TME Tumor Microenvironment
TNF-α Tumor Necrosis Factor Alpha
TRAF2 TNF Receptor-Associated Factor 2
UPR Unfolded Protein Response
VEGF Vascular Endothelial Growth Factor
VEGFA Vascular Endothelial Growth Factor A
VEGFR Vascular Endothelial Growth Factor Receptor
VEGFR2 Vascular Endothelial Growth Factor Receptor 2
VLDL Very Low-Density Lipoprotein
Wnt Wingless-Related Integration Site
XBP1 X-Box Binding Protein 1
XBP1s Spliced X-Box Binding Protein 1 (active transcription factor)
XIAP X-Linked Inhibitor of Apoptosis Protein
YAP/TAZ Yes-Associated Protein/Transcriptional Coactivator with PDZ-Binding Motif