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Model for how the interaction between hUpf1 and hDcp proteins may play a role in NMD. The EJC is deposited onto the mRNA upstream of exon-exon junctions after pre-mRNA splicing. hUpf3 associates with the EJC, followed by hUpf2 and hUpf1. A translation termination event upstream of the EJC/hUpf complex may allow hUpf1 to recruit the hDcp proteins to trigger mRNA decapping. RF, translation release factor.
