Fig. 1.

D50-modeling of disease progression (n = 526). A ALSFRS-R total scores over time of survival from onset in months (n = 526) with all individual scores per patient. B ALSFRS-R total scores over the time of survival from symptom onset in months with indicated D50-values (timepoint of 50% loss of motor function). C Normalizing real time months to the individual D50 values translates disease trajectory rD50, showing that disease aggressiveness subgroups go through the same form of functional decline during their individual disease course, and calculated for each ALSFRS-R sampling date with one representative patient per disease aggressiveness subgroup. Red = high (D50 ≤ 20 months), yellow = intermediate (20 < D50 < 40 months), blue = low aggressive disease (D50 ≥ 40 months)