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[Preprint]. 2026 Jul 15:2026.07.13.26358006. [Version 1] doi: 10.64898/2026.07.13.26358006

Figure 2: Colocalization analysis validating MR-identified plasma protein-IDP associations.

Figure 2:

(A) Summary of cis-pQTL-IDP pairs with strong evidence of colocalization, defined as the posterior probability of a shared causal variant (H4 > 0.7). “coloc” denotes results from the single causal variant model (coloc.abf), while “SuSiE” denotes the fine-mapping based approach (SuSiE-coloc). For pairs analyzed by both methods, the higher H4 value is shown. (B) Regional LocusZoom plots illustrating colocalized associations between PTHLH pQTLs and corresponding IDP GWAS signals (H4 > 0.7).