Figure 4. Summary of brain single-cell cis-eQTL effects on plasma protein levels.

Heatmaps display the Mendelian randomization-derived associations between cell-type-specific gene expression and corresponding plasma protein levels for the full cohort (A) and control-only samples (B). Colors and symbols indicate the direction and statistical strength of the associations: dark green with a plus (+) symbol denotes a significant positive association, while light green indicates a non-significant positive trend. Dark orange with a minus (−) symbol denotes a significant negative association, and light orange represents a non-significant negative trend. Gray shading indicates protein-cell type combinations without a valid single-SNP instrument.