Table 1.
Summary of Mendelian randomization (MR) results for imaging-derived phenotypes using cis- and trans-pQTLs from the UK Biobank Pharma Proteomics Project (UKB-PPP) and the deCODE study
| pQTL: MR method |
Total number of tests |
Number of proteins analyzed |
Number of significant MR findings |
Number of unique proteins in significant findings |
Number of unique IDPs in significant findings |
|
|---|---|---|---|---|---|---|
| UKB-PPP | Cis: Wald ratio | 1,129,236 | 2,031 | 309 | 57 | 164 |
| Cis: WM | 669,760 | 969 | 18 | 6 | 18 | |
| Cis: IVW | 868,894 | 1,167 | 70 | 11 | 61 | |
| Trans: WM | 1,243,242 | 2,079 | 10 | 8 | 8 | |
| deCODE | Cis: Wald ratio | 929,076 | 1,167 | 286 | 42 | 195 |
| Cis: WM | 579,462 | 1,120 | 9 | 3 | 10 | |
| Cis: IVW | 697,866 | 1,453 | 11 | 7 | 11 | |
| Trans: WM | 1,356,862 | 2,269 | 10 | 6 | 10 |
IDP: imaging derived phenotype; WM: weighted median MR estimate; IVW: inverse-variance weighted MR estimate.