Table 3. Biologic asthma response score (BARS) after switching to a different biologic therapy in severe asthma in the GAN registry 2011 – 2024.

Item		Anti-IgE – anti-IL5	Anti-IgE – anti-IL4R	Anti-IL5 – anti-IL5R	Anti-IL5 – anti-IL4R	Anti-IL5R – anti-IL4R
BARS I (mean)	N	8	17	42	24	34
	Mean (SD)	1.11 (0.66)	1.07 (0.61)	1.05 (0.76)	1.13 (0.79)	1.16 (0.69)
	Median	1.17	1.00	1.00	1.00	1.33
	IQR	1.00 – 1.33	0.50 – 1.50	0.50 – 1.83	0.50 – 2.00	0.67 – 1.67
	Missing values	2	7	14	7	13
BARS I (grouped)	N	8	17	42	24	34
	No response	1 (16.7%)	1 (10.0%)	6 (21.4%)	3 (17.6%)	4 (19.0%)
	Intermediate response	4 (66.7%)	5 (50.0%)	10 (35.7%)	6 (35.3%)	7 (33.3%)
	Good response	1 (16.7%)	4 (40.0%)	12 (42.9%)	8 (47.1%)	10 (47.6%)
	Missing values	2	7	14	7	13
BARS II (mean)	N	8	17	42	24	34
	Mean (SD)	0.87 (0.54)	1.02 (0.49)	0.89 (0.69)	0.94 (0.80)	1.02 (0.60)
	Median	1.00	1.00	0.88	1.00	1.25
	IQR	0.75 – 1.25	0.67 – 1.33	0.00 – 1.67	0.00 – 1.67	0.50 – 1.50
	Missing values	3	8	20	13	19
BARS II (grouped)	N	8	17	42	24	34
	No response	1 (20.0%)	2 (22.2%)	6 (27.3%)	4 (36.4%)	3 (20.0%)
	Intermediate response	4 (80.0%)	5 (55.6%)	10 (45.5%)	3 (27.3%)	8 (53.3%)
	Good response	–	2 (22.2%)	6 (27.3%)	4 (36.4%)	4 (26.7%)
	Missing values	3	8	20	13	19

BARS I = mean score taking into account exacerbations, oral corticosteroid therapy, and ACT score; BARS II = mean score taking into account exacerbations, oral corticosteroid therapy, ACT score, and FEV₁. ACT = asthma control test; anti-IgE = anti-immunoglobulin E; anti-IL5 = anti-interleukin-5; anti-IL5R = anti-interleukin-5 receptor; anti-IL4R = anti-interleukin-4 alpha receptor; anti-TSLP = anti-thymic stromal lymphopoietin; BARS = Biologic Asthma Response Score [10]; GAN = German Asthma Net; SD = standard deviation; IQR = interquartile range.