| ACC | Anterior Cingulate Cortex |
| ADC | Apparent Diffusion Coefficient |
| AFDtot | Apparent Fiber Density Total |
| AUDIT | Alcohol Use Disorders Identification Test |
| BDI | Beck Depression Inventory |
| BDI-II | Beck Depression Inventory-II |
| BOLD | Blood Oxygen Level-Dependent |
| CES-D | Center for Epidemiologic Studies Depression Scale |
| CMDI | Chicago Multiscale Depression Inventory |
| CSF | Cerebrospinal Fluid |
| DIR | Double Inversion Recovery |
| DMN | Default Mode Network |
| DSM-V | Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition |
| DTI | Diffusion Tensor Imaging |
| DWI | Diffusion-Weighted Imaging |
| ECN | Executive Control Network |
| EDSS | Expanded Disability Status Scale |
| EPI | Echo Planar Imaging |
| FA | Fractional Anisotropy |
| FC | Functional Connectivity |
| FLAIR | Fluid-Attenuated Inversion Recovery |
| fMRI | Functional Magnetic Resonance Imaging |
| FSS | Fatigue Severity Scale |
| FWF | Free Water Fraction |
| Gad+ | Gadolinium-Enhancing |
| GGT | Gamma-Glutamyl Transferase |
| GM | Gray Matter |
| GRE | Gradient Recalled Echo |
| HADS | Hospital Anxiety and Depression Scale |
| HADS-A | Hospital Anxiety and Depression Scale—Anxiety |
| HADS-D | Hospital Anxiety and Depression Scale—Depression |
| HARDI | High Angular Resolution Diffusion Imaging |
| HDRS | Hamilton Depression Rating Scale |
| HPA | Hypothalamic–Pituitary–Adrenal |
| HRQoL | Health-Related Quality of Life |
| MADRS | Montgomery–Åsberg Depression Rating Scale |
| MD | Mean Diffusivity |
| MMSE | Mini-Mental State Examination |
| MP-RAGE | Magnetization Prepared Rapid Gradient Echo |
| MPR2RAGE | Magnetization Prepared 2 Rapid Gradient Echoes |
| MPRAGE | Magnetization Prepared Rapid Acquisition Gradient Echo |
| MRI | Magnetic Resonance Imaging |
| MS | Multiple Sclerosis |
| N/A | Not Applicable |
| NAWM | Normal-Appearing White Matter |
| NHPT | Nine-Hole Peg Test |
| NuFO | Number of Fiber Orientations |
| OFC | Orbitofrontal Cortex |
| PCC | Posterior Cingulate Cortex |
| PD | Proton Density |
| PFC | Prefrontal Cortex |
| PHQ-2 | Patient Health Questionnaire-2 |
| PHQ-9 | Patient Health Questionnaire-9 |
| PROMIS | Patient-Reported Outcomes Measurement Information System |
| PwMS | People with Multiple Sclerosis |
| RD | Radial Diffusivity |
| ROI | Region of Interest |
| RRMS | Relapsing–Remitting Multiple Sclerosis |
| rs-fMRI | Resting-State Functional Magnetic Resonance Imaging |
| S-ANX | State Anxiety |
| SN | Salience Network |
| SPMS | Secondary Progressive Multiple Sclerosis |
| STAI | State-Trait Anxiety Inventory |
| STAI-T | State-Trait Anxiety Inventory—Trait |
| STAIS-5 | State Anxiety Inventory Short Form |
| STAIT-5 | Trait Anxiety Inventory Short Form |
| SVR | Support Vector Regression |
| T-ANX | Trait Anxiety |
| T1W | T1-Weighted |
| T2LL | T2 Lesion Load |
| T2W | T2-Weighted |
| UF | Uncinate Fasciculus |
| VBM | Voxel-Based Morphometry |
| WM | White Matter |
| WML | White Matter Lesion |
| WMLL | White Matter Lesion Load |