AGE-RAGE	Advanced glycation end products–receptor for advanced glycation end products
AMPK	AMP-activated protein kinase
BMD	Bone mineral density
BMI	Body mass index
CT	Non-osteoporotic controls
DEGs	Differentially expressed genes
HB	Matched healthy bone
HIF-1	Hypoxia-inducible factor 1
IL-17	Interleukin 17
IMSS	Mexican Institute of Social Security
INMEGEN	National Institute of Genomic Medicine
INRLGII	Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”
logFC	Log fold-change
MAPK	Mitogen-activated protein kinase
MHWCS	Mexican Health Worker Cohort Study
NF-κB	Nuclear factor kappa B
NOD	Nucleotide-binding oligomerization domain
OP	Osteoporosis
OS	Osteosarcoma
PC1	Principal component 1
PC2	Principal component 2
PCA	Principal component analysis
PI3K-Akt	Phosphoinositide 3-kinase–protein kinase B
PPAR	Peroxisome proliferator-activated receptor
RNA-seq	RNA sequencing
TNF	Tumor necrosis factor