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. 2026 Jul 17;27(14):6362. doi: 10.3390/ijms27146362
AFP Alpha-fetoprotein
α-SMA alpha-smooth muscle actin
CA125 Carbohydrate antigen 125
CA19-9 Carbohydrate antigen 19-9
CAF Cancer-associated fibroblast
CCA Cholangiocarcinoma
CEA Carcinoembryonic antigen
ceRNA Competitive endogenous RNA
circRNA Circular RNA
COX-2 Cyclooxygenase-2
CSC Cancer stem-like cell
CXCR4 C-X-C chemokine receptor 4
dCCA Distal cholangiocarcinoma
eCCA Extrahepatic cholangiocarcinoma
ECM Extracellular matrix
EGF Epidermal growth factor
EGFR Epidermal growth factor receptor
EMT Epithelial–mesenchymal transition
FGF Fibroblast growth factor
FXR Farnesoid X receptor
HCC Hepatocellular carcinoma
HGF Hepatocyte growth factor
HIF-1 Hypoxia-inducible factor-1
HRE Hypoxia response element
iCCA Intrahepatic cholangiocarcinoma
ICD Immunogenic cell death
IHC Immunohistochemistry
lncRNA Long non-coding RNA
m6A N6-methyladenosine
MAIT Mucosal-associated invariant T
MDR1 Multidrug resistance gene 1
NGS Next-generation sequencing
pCCA Perihilar cholangiocarcinoma
PDGF Platelet-derived growth factor
PSC Primary sclerosing cholangitis
RTK Receptor tyrosine kinase family
scRNA-seq Single-cell RNA sequencing
ST Spatial transcriptomics
TAM Tumor-associated macrophage
TGF Transforming growth factor
TME Tumor microenvironment
TNF Tumor necrosis factor
VEGF Vascular endothelial growth factor
VEGFRs VEGF receptors