Table 2.
Radiological response to treatment
| After induction (n=31) | 20th cCRT (n=30) | 1 month post-cCRT (n=30) | |
| Overall tumor site | |||
| CR | 8 (25.8) | 24 (80.0) | 28 (93.3) |
| PR | 19 (61.3) | 6 (20.0) | 2 (6.7) |
| Reduction of ≥70% in tumor size | 14 (45.2) | 3 (10.0) | 0 |
| Reduction of ≥30% to <70% in tumor size | 5 (16.1) | 3 (10.0) | 2 (6.7) |
| SD | 4 (12.9) | 0 | 0 |
| PD | 0 | 0 | 0 |
| ORR | 27 (87.1; 70.2 to 96.4) | 30 (100.0; 88.8 to 100.0) | 30 (100.0; 88.8 to 100.0) |
| DCR | 31 (100.0; 88.4 to 100.0) | 30 (100.0; 88.8 to 100.0) | 30 (100.0; 88.8 to 100.0) |
| Response at primary sites | |||
| CR | 22 (71.0) | 27 (90.0) | 29 (96.7) |
| PR | 7 (22.6) | 3 (10.0) | 1 (3.3) |
| Reduction of ≥70% in tumor size | 3 (9.7) | 1 (3.3) | 0 |
| Reduction of ≥30% to <70% in tumor size | 4 (12.9) | 2 (6.7) | 1 (3.3) |
| SD | 2 (6.5) | 0 | 0 |
| PD | 0 | 0 | 0 |
| Response at lymph nodes | |||
| CR | 14 (45.2) | 25 (83.3) | 29 (96.7) |
| PR | 13 (41.9) | 5 (16.7) | 1 (3.3) |
| Reduction of ≥70% in tumor size | 11 (35.5) | 2 (6.7) | 0 |
| Reduction of ≥30% to <70% in tumor size | 2 (6.5) | 3 (10.0) | 1 (3.3) |
| SD | 4 (12.9) | 0 | 0 |
| PD | 0 | 0 | 0 |
Data are n (%) or n (%, 95% CI). Efficacy was analyzed in treated patients who had baseline and post-baseline imaging assessment after induction chemoimmunotherapy, after 20 fractions of radiotherapy, and 1 month after cCRT.
cCRT, concurrent chemoradiotherapy; CR, complete response; DCR, disease control rate; ORR, objective response rate; PD, disease progression; PR, partial response; SD, stable disease; 20th cCRT, 20 fractions of radiotherapy.