Abbreviation	Definition
AE	adverse event
AKI	acute kidney injury
ALT	alanine aminotransferase
AST	aspartate aminotransferase
BID	twice daily
BMI	body mass index
CI	confidence interval
DB	double blind
DBP	diastolic blood pressure
EFSA	European Food Safety Authority
FPG	fasting plasma glucose
GRADE	Grading of Recommendations Assessment, Development and Evaluation
HbA1c	glycated hemoglobin
HDL-C	high-density lipoprotein cholesterol
HOMA-IR	homeostatic model assessment of insulin resistance
LDL-C	low-density lipoprotein cholesterol
MIB-626	microcrystalline β-nicotinamide mononucleotide formulation
NAD+	nicotinamide adenine dinucleotide
NMN	nicotinamide mononucleotide
NR	not reported
OR	odds ratio
PC	Placebo controlled
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
QD	once daily
RCT	randomized controlled trial
RD	risk difference
RoB	risk of bias
SAE	serious adverse event
SBP	systolic blood pressure
SMD	standardized mean difference
T2DM	type 2 diabetes mellitus
TC	total cholesterol
TG	triglyceride