Figure 4: The COC proteome parallels the transcriptome following PCSK-inhibition.

A) Schematic showing methodology for collecting COCs for proteomics. IVM = in vitro maturation. B) Volcano plot showing proteins up- and down-regulated with PCI treatment of COCs. C) Heatmap showing differential protein expression in CTL vs. PCI-treated COCs. D) Bar graph showing core and matrisome-associated proteins dysregulated with PCI treatment. E) Bar graph showing number of up- and downregulated proteins across functional categories. F) Heatmaps showing specific proteins related to matrix remodeling, adhesion/migration, signaling, or stress responses that are altered with PCI treatment. G) Graph showing correlation between transcriptomic and proteomic data of CTL vs. PCI treated COCs at 8h and 10h of IVM, respectively.