Table 2.

AML per-cell mutation-label validation using cell-state-residual scores. “Comparison” required an explicit wild-type transcript annotation without a contradictory mutant annotation; it does not establish complete genomic wild type.

Driver	Mutant	Comparison	Apparent AUROC	Cliff’s δ	FDR q
NPM1	542	1457	0.753	0.506	7.3 × 10−67
TP53	51	25	0.743	0.485	2.5 × 10−3
DNMT3A	146	404	0.714	0.429	9.4 × 10−14
RAD21	9	187	0.708	0.417	0.106
SMC3	7	19	0.684	0.368	0.338
NRAS	36	114	0.601	0.203	0.162
FLT3	46	124	0.558	0.116	0.425
KIT	23	36	0.502	0.005	0.981
RUNX1	23	25	0.485	−0.030	0.948
TET2	18	30	0.454	−0.093	0.722
IDH2	2	228	0.329	−0.342	0.585
KRAS	2	41	0.317	−0.366	0.585