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. 2002 Aug 15;30(16):3548–3557. doi: 10.1093/nar/gkf480

Figure 4.

Figure 4

URE multimerisation increases exon 3 skipping. Constructs containing 0, 1, 2, 3, 4, 6 and 8 copies of the URE were transfected into PAC-1 SM cells, L cells, HeLa cells and C2C12 myoblasts (A–D) and analysed as in Figure 2. (E) Histogram representation of the data from (A) to (D). (F) Histogram representation of splicing regulation. The degree of regulation for each construct was calculated as the ratio of exon skipping in SM cells compared with the other non-muscle (L, HeLa and C2C12) cell types. URE multimerisation increases exon 3 skipping in all cells but decreases splicing regulation in SM/non-SM cells.