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. 2002 Aug 15;30(16):3548–3557. doi: 10.1093/nar/gkf480

Figure 6.

Figure 6

Enhanced exon skipping by DUGC multimers. PAC-1, L, HeLa and C2C12 cells (A–D) were transiently transfected with constructs containing 1–4 copies of the DUGC element or 2, 3 or 6 copies of the URE sequence in the DUGC position. The nomenclature of the mutant constructs shows that each construct contains a wild-type URE, indicated before the forward slash. The number and type of sequence element in the DUGC position is indicated after the forward slash. For example, URE/4DUGC has four copies of the DUGC element. Data were analysed as in Figure 2. (E) Histogram of per cent exon skipping for each construct in each cell type. (F) Histogram of regulation of each construct, expressed as per cent exon skipping in SM cells/per cent exon skipping in HeLa, L or C2C12 cells.