Table 1.

Detection and segmentation performance comparisons of the 6 nnU-Net models on Testing Data Set 1

Model	Overall sensitivity (all lesions)	Average Sensitivity (per patient)	FP rate	HD95/Avg. HD	DSC
nnU-Net	0.903	0.937 ± 0.136 95% CI: 0.917–0.956	1.79 ± 1.79 95% CI: 1.52–2.04	2.20 ± 3.70/ 0.40 ± 0.91	0.675 ± 0.168
nnU-Net with ADS	0.894	0.934 ± 0.139 95% CI: 0.914–0.954	0.91 ± 1.27 95% CI: 0.73–1.10	1.47 ± 1.26/ 0.25 ± 0.29	0.726 ± 0.149
nnU-Net with ADS and 643 patch size	0.894	0.925 ± 0.151 95% CI: 0.903–0.947	3.26 ± 2.07 95% CI: 2.96–3.57	1.67 ± 1.98/ 0.29 ± 0.56	0.710 ± 0.157
nnU-Net with ADS and batch size 5	0.906	0.940 ± 0.130 95% CI: 0.921–0.958	1.21 ± 1.51 95% CI: 0.99–1.43	2.00 ± 2.90/ 0.36 ± 0.78	0.678 ± 0.162
nnU-Net with ADL	0.904	0.930 ± 0.156 95% CI: 0.907–0.952	0.65 ± 1.17 95% CI: 0.48–0.82	1.45 ± 1.91/ 0.23 ± 0.42	0.758 ± 0.145
nnU-Net with ADS and ADL	0.895	0.918 ± 0.175 95% CI: 0.893–0.943	0.66 ± 1.14 95% CI: 0.49–0.83	1.46 ± 1.54/ 0.23 ± 0.33	0.758 ± 0.149

Abbreviations: Average sensitivity = average of metastasis-level sensitivity per patient over all patients; Avg HD = the average Hausdorff distance of detected true positive brain metastases in mm; DSC = Dice similarity coefficient of detected true positive brain metastases; FP rate = false-positive rate; HD95 = the 95 percentile Hausdorff distance of detected true positive brain metastases in mm; mean ± standard deviation; overall sensitivity = lesion-level sensitivity.