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. Author manuscript; available in PMC: 2026 Aug 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2024 Jul 25;121(1):241–249. doi: 10.1016/j.ijrobp.2024.07.2318

Table 2.

Segmentation performance comparisons of the 6 nnU-Net models on small BMs (0.004–0.1 cm3, ESD 2–6 mm) of Testing Data Set 1

Model Overall sensitivity (all lesions) HD95/Avg. HD DSC
nnU-Net 0.820 1.83 ± 3.41
(0.44 ± 0.99)
0.591 ± 0.178
nnU-Net with ADS 0.807 1.32 ± 1.33
(0.30 ± 0.38)
0.646 ± 0.149
nnU-Net with ADS and 643 patch size 0.807 1.56 ± 2.73
(0.37 ± 0.83)
0.629 ± 0.172
nnU-Net with ADS and batch size 5 0.829 1.66 ± 2.77
(0.39 ± 0.82)
0.603 ± 0.170
nnU-Net with ADL 0.824 1.09 ± 0.48
(0.23 ± 0.15)
0.707 ± 0.139
nnU-Net with ADS and ADL 0.814 1.10 ± 0.50
(0.23 ± 0.15)
0.710 ± 0.141

Operating points were set at the same as all size brain metastases in Table 1.

Abbreviations: Avg HD = the average Hausdorff distance of detected true positive brain metastases in mm; DSC = Dice similarity coefficient of detected true positive brain metastases; HD95 = the 95 percentile Hausdorff distance of detected true positive brain metastases in mm; mean ± standard deviation; overall sensitivity = lesion-level sensitivity.