Figure 4. Graphic Representation of the Evolutionary Relationship between Mouse, Human, and Chimpanzee ABCA1 Proteins.

ABCA1 amino acid position 883 genotype is displayed under the species name. An “X” represents the likely point in evolutionary history at which the V883→M883 and M883→I883 mutation events occurred. The M883→I883 mutation likely occurred since the divergence of the last common ancestor between humans and chimpanzees, and the increased activity of the I883 allele suggests that this may have been one of the adaptive changes that occurred during the evolution of modern humans.